Publications in Google Scholar



Hormozdiari F, Zhu A, Kichaev G, Ju CJT, Segre AV, Joo JW, Won H, Sankararaman S, Pasaniuc B, Shifman S and Eskin E (2017) Widespread allelic heterogeneity in complex traits. American Journal of Human Genetics

Shohat S, Ben-David E, Shifman S. (2017) Varying Intolerance of Gene Pathways to Mutational Classes Explain Genetic Convergence across Neuropsychiatric Disorders. Cell Reports


Kang EY, Martin L, Mangul S, Isvilanonda W, Zou J, Ben-David E, Han B, Lusis AJ, Shifman S, Eskin E. (2016) Discovering SNPs Regulating Human Gene Expression Using Allele Specific Expression from RNA-Seq Data. Genetics


Ben-David E, Bester AC, Shifman S, Kerem B. (2014) Transcriptional dynamics in colorectal carcinogenesis: new insights into the role of c-Myc and miR-17 in benign to cancer transformation. Cancer Research

Shahar S, Shifman S. (2014) Bias towards large genes in autism. Nature 5:81

Hanin G, Shenhar-Tsarfaty S, Yayon N, Hoe YY, Bennett ER, Sklan EH, Rao DC, Rankinen T, Bouchard C, Geifman-Shochat S, Shifman S, Greenberg DS, Soreq H. (2014) Competing targets of microRNA-608 affect anxiety and hypertension. Human Molecular Genetics

Suliman R, Ben-David E, Shifman S. (2014) Chromatin regulators, phenotypic robustness and autism risk. Front Genet 5:81

Ben-David E, Shohat S, Shifman S. (2014) Allelic expression analysis in the brain suggests a role for heterogeneous insults affecting epigenetic processes in autism spectrum disorders. Human Molecular Genetics

Barbash S, Shifman S and Soreq H. (2014) Global co-evolution of human microRNAs and their target genes. Molecular biology and evolution


Pandey V, Turm H, Bekenstein U, Shifman S and Kadener S. (2013) A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis. Front Cell Neurosci 7:146

Ben-David E, Shifman S. (2013) Combined analysis of exome sequencing points toward a major role for transcription regulation during brain development in autism. Molecular Psychiatry 18:1054-1056


Brunschwig H, Levi L, Ben-David E, Williams RW, Yakir B, Shifman S. (2012) Fine-scale map of recombination rates and hotspots in the mouse genome. GENETICS 191(3):757-764

Huang GJ, Ben-David E, Tort Piella A, Edwards A, Flint J, Shifman S. (2012) Neurogenomic evidence for a shared mechanism of the antidepressant effects of exercise and chronic fluoxetine in mice. PLoS ONE 7(4): e35901.

Ben-David E, Shifman S. (2012) Networks of neuronal genes affected by common and rare variants in autism spectrum disorders. PLoS Genetics 8(3): e1002556.


Ben-David E, Granot-Hershkovitz E, Monderer-Rothkoff G, Lerer E, Levi S, Yaari M, Ebstein RP, Yirmiya N, Shifman S. (2011) Identification of a functional rare variant in autism using genome-wide screen for monoallelic expression. Human Molecular Genetics 20:3632-3641.

Ovadia G, Shifman S. (2011) The Genetic Variation of RELN Expression in Schizophrenia and Bipolar Disorder. PLoS ONE 6:e19955


Ben-David E, Shifman S. (2010) Further investigation of the association between rs7341475 and rs17746501 and schizophrenia. Am J Med Genet B Neuropsychiatr Genet 153B:1244-1247

Narwani K, Biancotti JC, Golan-Lev T, Buehler N, Hill D, Shifman S, Benvenisty N, Lavon N. (2010) Human embryonic stem cells from aneuploid blastocysts identified by pre-implantation genetic screening. In Vitro Cell Dev Biol Anim 46: 309-316


Huang GJ, Shifman S, Valdar W, Johannesson M, Yalcin B, Taylor MS, Taylor J, Mott R, Flint J. (2009) High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues. Genome Res 19:1133-1140

O'Donovan MC, Norton N, Williams H, Peirce T, Moskvina V, et al. (2009) Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2. Mol Psychiatry 14:30-36


O'Donovan MC, Craddock N, Norton N, Williams H, Peirce T, et al. (2008) Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet 40: 1053-1055

Flint J and Shifman S (2008) Animal models of psychiatric disease. Curr Opin Genet Dev 18: 235-240

Shifman S, Johannesson M, Bronstein M, Chen SX, Collier DA, et al. (2008) Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. PLoS Genet 4: e28

Shifman S, Bhomra A, Smiley S, Wray NR, James MR, et al. (2008) A whole genome association study of neuroticism using DNA pooling. Mol Psychiatry 13: 302-312

Fullerton JM, Willis-Owen SA, Yalcin B, Shifman S, Copley RR, et al. (2008) Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus. Biol Psychiatry 63: 874-883


Shifman S, Bell JT, Copley RR, Taylor MS, Mott R, et al. (2007) Evidence of a Large-Scale Functional Organization of Mammalian Chromosomes: Authors' Reply. PLoS Biol 5: e128

Martin J, Cleak J, Willis-Owen SA, Flint J, Shifman S (2007) Mapping regulatory variants for the serotonin transporter gene based on allelic expression imbalance. Mol Psychiatry 12: 881


Willis-Owen SA, Shifman S, Copley RR, Flint J (2006) DCNP1: a novel candidate gene for major depression. Mol Psychiatry 11: 121-122

Shifman S, Levit A, Chen ML, Chen CH, Bronstein M, et al. (2006) A complete genetic association scan of the 22q11 deletion region and functional evidence reveal an association between DGCR2 and schizophrenia. Hum Genet 120: 160-170

Shifman S, Bell JT, Copley RR, Taylor MS, Williams RW, et al. (2006) A high-resolution single nucleotide polymorphism genetic map of the mouse genome. PLoS Biol 4: e395

Shifman S, Darvasi A (2005) Mouse inbred strain sequence information and yin-yang crosses for quantitative trait locus fine mapping. Genetics 169: 849-854


Horowitz A, Shifman S, Rivlin N, Pisante A, Darvasi A (2005) A survey of the 22q11 microdeletion in a large cohort of schizophrenia patients. Schizophr Res 73: 263-267

Horowitz A, Shifman S, Rivlin N, Pisante A, Darvasi A (2005) Further tests of the association between schizophrenia and single nucleotide polymorphism markers at the catechol-O-methyltransferase locus in an Askenazi Jewish population using microsatellite markers. Psychiatr Genet 15: 163-169

Flint J, Valdar W, Shifman S, Mott R (2005) Strategies for mapping and cloning quantitative trait genes in rodents. Nat Rev Genet 6: 271-286

Darvasi A, Shifman S (2005) The beauty of admixture. Nat Genet 37: 118-119

Benmoyal-Segal L, Vander T, Shifman S, Bryk B, Ebstein RP, et al. (2005) Acetylcholinesterase/paraoxonase interactions increase the risk of insecticide-induced Parkinson's disease. Faseb J 19: 452-454


Shifman S, Bronstein M, Sternfeld M, Pisante A, Weizman A, et al. (2004) COMT: a common susceptibility gene in bipolar disorder and schizophrenia. Am J Med Genet B Neuropsychiatr Genet 128: 61-64


Shifman S, Kuypers J, Kokoris M, Yakir B, Darvasi A (2003) Linkage disequilibrium patterns of the human genome across populations. Hum Mol Genet 12: 771-776

Zak NB, Shifman S, Shalom A, Darvasi A (2002) Genetic dissection of common diseases. Isr Med Assoc J 4: 438-443


Shifman S, Pisante-Shalom A, Yakir B, Darvasi A (2002) Quantitative technologies for allele frequency estimation of SNPs in DNA pools. Mol Cell Probes 16: 429-434

Shifman S, Bronstein M, Sternfeld M, Pisante-Shalom A, Lev-Lehman E, et al. (2002) A highly significant association between a COMT haplotype and schizophrenia. Am J Hum Genet 71: 1296-1302

McGinnis R, Shifman S, Darvasi A (2002) Power and efficiency of the TDT and case-control design for association scans. Behav Genet 32: 135-144


Zak NB, Shifman S, Shalom A, Darvasi A (2001) Population-based gene discovery in the post-genomic era. Drug Discov Today 6: 1111-1115

Shifman S, Darvasi A (2001) The value of isolated populations. Nat Genet 28: 309-310

Shifman S, Cohen D (2001) The effect of anticipated learning on the choice of food sources in the fish Gambusia affinis. Behaviour 138: 287-298


Shifman S, Shacham B, Werner YL (1999) Tropiocolotes nattereri (Reptilia: Gekkonidae): comments on validity, variation and distribution. Zoology in the Middle East 17: 51-56