Citation:
O'Donovan, M.C. et al. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet 40, 1053-5 (2008). Copy at http://https://tinyurl.com/y5x79szd
Date Published:
2008 SepAbstract:
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 x 10(-4)), and the overall pattern of replication was unlikely to occur by chance (P = 9 x 10(-8)). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9)).